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Pyxis is a software for ion mobility mass spectrometry imaging (IMS-MSI), that supports both untargeted and targeted data analysis, distributed as desktop application. The workflow supported by Pyxis covers all the steps required for IMS-MSI data analysis: raw data processing, histological coregistration, image and mobilogram visualization, statistical analysis and automated metabolites identification.

Features

Data import

• Bruker timsTOF flex
• Waters SELECT SERIES Cyclic IMS

Data Analysis

• Peak detection and pre-processing, both on the m/z and mobility domains
• Spectral and image analysis
• Statistical Analysis: Segmentation, PCA, Colocalization
• Annotation and identification

Image Analysis

• Denoise, contrast enhancement, normalization
• Single and overlaid ion density images visualization
• Coregistration
• Possibility to cluster and visualize isobars images with different mobility values

Automation

• Background processing of computational intensive tasks
• Optimized and parallelized algorithms

System requirements

• Microsoft® Windows® 10 64 Bit operating system
• At least 32 GB of RAM (or superior)
• SATA III SSD 2T (or superior)
• Intel® Core™ i7 processor or Intel® Xeon® processor